In partnership with the communities we serve; we redouble our deep commitment to inclusion and diversity within our editorial, author and reviewer networks. Geneの研究領域には、これらのカテゴリが含まれます:

A=対象の雑誌が2017年に掲載した論文数; The index is based on the set of the scientist's A possible unifying hypothesis.

July doi: 10.1056/NEJMoa1406192, 73. Tu C, Nie H, Meng L, Wang W, Li H, Yuan S, et al. Similarly, the xenoestrogen bisphenol A stimulates mitochondrial ROS generation by human sperm mitochondria (129) as do certain polyphenols (epigallocatechin gallate, genistein, didox gossypol) several of which are traditionally regarded as antioxidants (130). Fertil Steril. (2017) 107:1312–8.e2. (2020). doi: 10.1002/cncr.10325, 221. (E) Major mechanisms by which DNA fragmentation on the Y is induced is through the aberrant recombination of repetitive elements (green) and deletion of the intervening DNA (blue). Zhang Y, Malekpour M, Al-Madani N, Kahrizi ZK, Zanganeh M, Mohseni M, et al. (2002) 78:1215–24. Nature Reviews Immunology, Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation. August

doi: 10.1016/j.gene.2017.08.033, 55. The latter is involved in establishing the spliceosome, a dynamic ribonucleoprotein complex responsible for orchestrating the processing of RNA during spermatogenesis, defects in which cause non-obstructive azoospermia (209). Int J Androl. (2018) 33:1973–84. Ann Hum Genet. Moye AR, Bedoni N, Cunningham JG, Sanzhaeva U, Tucker ES, Mathers P, et al. This locus maps to a genetic location which has linkages to male infertility, cancer, imprinting disorders and a variety of behavioral conditions (autism, bipolar disease, spontaneous schizophrenia) which have been linked to the age of the father at the moment of conception. Shang Y, Zhu F, Wang L, Ouyang YC, Dong MZ, Liu C, et al. Differences in blood and semen oxidative status in fertile and infertile men, and their relationship with sperm quality. (2012) 287:33048–60.

Gene 4-year Impact Factor Trend. Yuan P, Yang C, Ren Y, Yan J, Nie Y, Yan L, et al.

(2007) 14:727–33. (1995) 103:17–26. Liu T, Han Y, Zhou T, et al. Sha Y, Yang X, Mei L, Ji Z, Wang X, Ding L, et al. Li L, Feng F, Wang Y, Guo J, Yue W. Mutational effect of human CFAP43 splice-site variant causing multiple morphological abnormalities of the sperm flagella. That’s why every The overall rank of Gene Reports is 16985. December, All Journals

Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ, Agarwal A. Aitken RJ, De Iuliis GN, Nixon B. Koziorowska-Gilun M, Koziorowski M, Fraser L, Strzezek J. Antioxidant defence system of boar cauda epididymidal spermatozoa and reproductive tract fluids. A comparison of the NADPH oxidase in human sperm and white blood cells.

Colaco S, Modi D. Genetics of the human Y chromosome and its association with male infertility. (2020) 37:1431–9. The h-index is an author-level metric that attempts to measure both the productivity and citation The presence of small supernumerary marker chromosomes (sSMCs) is similarly associated with severe male infertility involving oligoasthenoteratozoospermia and most commonly involves chromosome 15 (211).

(2005) 437:100–3. (2012) 87:110. doi: 10.1095/biolreprod.112.102020, 122. (1994) 1214:171–9. Taylor JD, Baumgartner A, Schmid TE, Brinkworth MH. Some of these repetitive elements have become inverted to create palindromic sequences that facilitate recombination events in an area of the genome where inter-chromosomal recombination is otherwise suppressed. Gene strives to be a very diverse journal and topics in all fields will be considered for publication. !!! Inefficient or aberrant repair then fixes this damage as a mutation, either in the germline itself or in the newly fertilized oocyte. What are mirror journals, and can they offer a new world of open access? Mahfouz RZ, du Plessis SS, Aziz N, Sharma R, Sabanegh E, Agarwal A. doi: 10.1016/j.rbmo.2012.05.011, 181. (1996) 17:276–87. The major problem with all of these assessments is that the existence of male factor infertility was determined on the basis of a conventional semen profile. (2011) 46:527–33. Overall, more than 40 genes have been implicated in this heterogenous disease to date and the list of genes involved is expanding rapidly in concert with improvements in our understanding of ciliary structure and function. (1946) 158:485. doi: 10.1038/158485a0, 169. doi: 10.1210/jc.2007-2616, 114.
Sukcharoen N, Keith J, Irvine DS, Aitken RJ. (1997) 47:468–82. (2020) 52:e13551. Baker MA, Hetherington L, Curry B, Aitken RJ. AZFa and AZFb deletions usually result in complete azoospermia, with no current potential for treatment. An examination of 8OHdG lesions in the human sperm genome has revealed ~9,000 genomic regions vulnerable to oxidative attack in spermatozoa. A recent survey of papers that have set out to determine the causes of human infertility by assigning each case to one of four categories (male factor, female factor, both male and female factors, and unexplained) indicated that defects in the male were, on average (±SEM), thought to account for 21.1 ± 2.8% of all infertility, while the remaining causes distributed as follows: female factors (42.8 ± 3.2%), combined male and female factors (24.2 ± 4.9%) and unexplained infertility (13.2 ± 2.1%) (1). Mitochondrial ROS are also produced as part of the intrinsic apoptotic cascade that becomes activated whenever the phosphoinositide signaling pathway is compromised (114). A related syndrome is “partial globozoospermia” where >50% of cells exhibit the round-headed acrosomeless morphology (14). Such monogenic mutations aside, the most common genetic causes of male infertility are aneuploidies such as Klinefelter syndrome and Y-chromosome mutations which together account for around 20–25% of all cases of non-obstructive azoospermia. doi: 10.1093/oxfordjournals.humrep.a136470, 5. Consequently, a large number of studies, conducted in a range of different species, have examined the impact of antioxidants on post-thaw functionality. (2014) 51:61–7. Hum Reprod. Nature. Stimulation of oxidant generation by human sperm suspensions using phorbol esters and formyl peptides: relationships with motility and fertilization in vitro. Analysis of the relationship between reactive oxygen species production and leucocyte infiltration in fractions of human semen separated on percoll gradients. (2018) 27:1196–211.

Gene 2019-20年の最新のインパクトファクターパーティション： Reproduction. doi: 10.1074/jbc.M112.366690, 144.

However, if PI3K activity is disrupted, AKT and its downstream target, BAD, become dephosphorylated allowing the latter to escape from the grip of its 14-3-3 keeper to form a heterodimer with Bcl-2 and Bcl-xL, inactivating these regulators and thus allowing Bax/Bak-triggered apoptosis.
Source: https://www.scimagojr.com/journalrank.php, January Detailed analysis of reactive oxygen species induced by visible light in various cell types. Cookies are used by this site. Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. doi: 10.1093/humrep/dez308.

The importance of oxidative stress in determining the functionality of mammalian spermatozoa: a two-edged sword. Note: The impact factor shown here is equivalent to citescore and is, therefore, used as a replacement for the same. The diagnostic value of the conventional semen profile lies only in its ability to reflect the quality of the underlying spermatogenic process. Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. doi: 10.1016/j.freeradbiomed.2015.01.015, 111.

In addition to antioxidant administration we should also recognize that a variety of lifestyle interventions might also influence the oxidative stress underpinning male infertility including, increased exercise, improved diet as well as the cessation of alcohol consumption and cigarette smoking. Kissin DM, Zhang Y, Boulet SL, Fountain C, Bearman P, Schieve L, et al. Saudi J Biol Sci. 192.

doi: 10.1136/jmedgenet-2013-101938, 31. The intrinsic apoptotic cascade is associated with rapid motility loss, mitochondrial ROS generation, caspase activation in the cytosol, annexin V binding to the cell surface, cytoplasmic vacuolization and oxidative DNA damage (Figure 3) (114). (2016) 31:252–62. Antioxidants. Effects of radiofrequency electromagnetic waves (RF-EMW) from cellular phones on human ejaculated semen: an in vitro pilot study. Identification of pathogenic mutations and investigation of the notch pathway activation in Kartagener syndrome. Fertil Steril. Sci Rep. (2014) 4:4689. doi: 10.1038/srep04689, 201. Another factor in the oxidative stress equation that may be upregulated in spermatozoa possessing excess residual cytoplasm is lipoxygenase. Clin Endocrinol. The latter activate the H(V)1 proton channel leading to proton extrusion and alkalinization of the cytoplasm.

28. Bize I, Santander G, Cabello P, Driscoll D, Sharpe C. Hydrogen peroxide is involved in hamster sperm capacitation in vitro. doi: 10.1073/pnas.1901259116, 84. SNIP (Source Normalized Impact per Paper) can provide you comprehensive insights into the Gene. a variety of environmental and lifestyle factors including age, smoking, infertility, obesity, exposure to a range of xenobiotic toxicants, radiofrequency electromagnetic radiation, heat and cryopreservation (213, 225, 226) conspire to generate oxidative DNA damage and fragmentation in the male germline.

Mitochondrial DNA. Dam AH, Ramos L, Dijkman HB, Woestenenk R, Robben H, van den Hoven L, et al. Afzelius BA. However, there is still some conjecture as to how many other factors are involved in sperm motility loss in vitro.

Armstrong JS, Bivalacqua TJ, Chamulitrat W, Sikka S, Hellstrom WJ. The best quartile for this journal is Q4. (2020) 12:e13624. Review Speed, Determinants of human sperm quality. Houston BJ, Nixon B, Martin JH, De Iuliis GN, Trigg NA, Bromfield EG, et al. (2000) 21:145–53. Hum Reprod Update. Reproduction. Gene has an open access mirror journal Gene: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Tosic J, Walton A. Metabolism of spermatozoa.

(2008) 89:602–7. ACM The major DPY19L2 deletion is thought to have stabilized at a low level within the population because the de novo production of mutant alleles balances the negative selection incurred by sterile homozygous males (18). Endocrinol. J Assist Reprod Genet. doi: 10.4103/ijmr.IJMR_1988_17, 193. J Assist Reprod Genet. Biochem J. (2018) 2018:5076271. doi: 10.1155/2018/5076271, 136. Enter journal title, issn or abbr in this box to search. The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric factor based on the yearly average number of citations on articles published by a particular journal in the last two years. Iran J Med Sci. . Nature. Free Radic Biol Med. With the exception of patients exhibiting azoospermia or certain genetic defects such as Kartagener syndrome, most males are on a continuum of relative fertility. Genetic aspects of monomorphic teratozoospermia: a review. Fertil Steril. November